Now, it’s essential to state right here that Schwimmer and Aniston may not be dating. And so, when I used to be placing this together, I was trying to suppose via how — the way you guys may model issues. I believe what I might highlight is that, we are particularly pleased with the uptick in the hospital setting. So simply from the view of Lantheus on staffing shortages, any information points you can share on, on perhaps how lengthy this headwind will final later into this 12 months and maybe in the following? But when it comes to some of the other targets, we remain dedicated to the — in our 800 foundation factors over the following three years, and that’s achievable. One of the drivers of the 12 months-over-year variance, pertains to the accounts receivable stability, rising as a consequence of ramping PYLARIFY sales in the quarter and related receipt terms with prospects. The rise is due partially to the impression of COVID-19 on cost in the prior yr comparison. Turning now to steerage for Q4 and the full 12 months; we forecast revenue to be in a range of $110 million to $115 million for the fourth quarter of 2021, an increase of roughly 17% and 22% over the fourth quarter of 2020. The vary takes recent PYLARIFY performance into consideration, in addition to a broadened view of other product contribution against a backdrop of assorted macro environmental pressures. Now turning to the quarter; revenue for the third quarter was $102.1 million, a rise of 15.3% over the prior yr quarter, and the comparison consists of our now divested Puerto Rico operation.
Switching now to DEFINITY; the third quarter saw double-digit growth yr-over-12 months in sales. At the beginning of the third quarter, our community lined roughly 6% of the U.S. We’ve continued to actively work with our PET manufacturing amenities or PMF channel companions to build out our PYLARIFY manufacturing and distribution network access throughout the U.S. We are tapping into the identical proven, wide scale PET manufacturing and distribution community for PYLARIFY. Are they inviting extra students in, so that they’ve good levels popping out of the packages, to ensure that on a go forward foundation, they’re bringing sufficient individuals into these applications? Good morning, Larry. So let’s just type of choose apart. It sounds like the income traits. I expect to see G&A stay fairly stable and get leverage, that as a percentage of income. Because the entry into hospitals, both for people’s willingness, in addition to from a gross sales rep capability to get into the hospital and do in-individual promotion, as well as a affected person’s willingness to go into that setting of care, which has all the time been one among our key tenets to our steering. Gross profit margin is barely decrease than our expectations for the quarter, based mostly on product mix, with barely lower contribution from DEFINITY, as I previously famous, in addition to lower than anticipated AZEDRA sales, in opposition to comparatively fixed overhead prices at our Somerset manufacturing facility.
But AZEDRA additionally from a site of care perspective, has a lot of out of hospital use, and plenty of the imaging centers are freestanding and they are not as dependent on hospital staffing, if you are speaking about considerations with general nursing staffing in hospitals. We are literally utilizing planes, trains and automobiles to even cover these markets that we’re not yet in, or to the service of this prostate most cancers neighborhood, which we feel is really benefited by the availability of PYLARIFY. We consider this will further facilitate the business adoption of PYLARIFY, as it raises awareness within the medical and payor communities of PSMA’s clinical relevance for physicians, in diagnosing and selecting remedy choices for prostate most cancers patients and the potential influence this novel PSMA targeted imaging agent can have in the overall treatment plan of men with prostate cancer.
Patients in the ARROW trial are followed from one year after their first remedy for all efficacy endpoints. PMF’s work with the imaging centers they serve to satisfy the needs of physicians ordering imaging studies for his or her patients. From a demand perspective, we have now been pleased with the breadth of ordering across our buyer base, with hospitals comprising roughly 65% of orders thus far, unbiased imaging centers 20%, and authorities facilities 15%. We have been significantly happy with the adoption by hospitals, a lot of which is in the hospital outpatient setting, even previous to go-through payment initiation. Similarly, we have now seen a ramp in PYLARIFY adoption. Simply a couple of comply with-ups on the PYLARIFY. This statement should not really be that stunning when one considers that age-gap dating, which was once mainly confined to older males in search of younger girls, has seen a significant upsurge in progress over the last 8-10 years-with both male and females now on the lookout for older or youthful companions, because the case may be. And as that — as we’ve seen the Delta variant form of wane just a little bit, that does not essentially imply that we think hospitals are going to instantly form of back off of their present coverage.